Therapeutic role of mTOR inhibitors in control of SARS-CoV-2 viral replicationReview Published on 2023-03-012023-07-11 Journal: Molecular biology reports [Category] COVID19(2023년), [키워드] autophagy coronavirus metformin mTOR inhibition. Skp2 [DOI] 10.1007/s11033-022-08188-1 PMC 바로가기 [Article Type] Review
Anti-hepatitis B virus activity of lithospermic acid, a polyphenol from Salvia miltiorrhiza, in vitro and in vivo by autophagy regulationArticle Published on 2023-02-102023-06-13 Journal: Journal of ethnopharmacology [Category] B형 간염, [키워드] Antiviral autophagy Hepatitis B virus Lithospermic acid polyphenols traditional Chinese medicine. [DOI] 10.1016/j.jep.2022.115896 PMC 바로가기
Dihydromyricetin inhibits Hepatitis B virus replication by activating NF-κB, MAPKs, and autophagy in HepG2.2.15 cellsArticle Published on 2023-02-012023-06-12 Journal: Molecular biology reports [Category] B형 간염, [키워드] autophagy Dihydromyricetin (DHM) Hepatitis B virus (HBV) Mitogen-activated protein kinases (MAPKs) Nuclear factor-kappa B (NF-κB). [DOI] 10.1007/s11033-022-07971-4 PMC 바로가기
Conserved requirement of autophagy-related effectors during coronavirus replicationArticle Published on 2023-02-012023-07-10 Journal: Autophagy [Category] COVID19(2023년), [키워드] antiviral target autophagy coronavirus CRISPR screen host factor. [DOI] 10.1080/15548627.2022.2100617 PMC 바로가기
PI3K/AKT-mediated autophagy inhibition facilitates mast cell activation to enhance severe inflammatory lung injury in influenza A virus- and secondary Staphylococcus aureus-infected miceArticle Published on 2023-01-012023-06-24 Journal: Antiviral Research [Category] 신종인플루엔자, [키워드] autophagy Inflammation influenza A virus mast cell secondary bacterial infection. [DOI] 10.1016/j.antiviral.2022.105502 PMC 바로가기
Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagyArticle Published on 2023-01-012023-06-11 Journal: Antiviral Research [Category] B형 간염, [키워드] AMPK autophagy Ciliatoside A Hepatitis B virusB surface antigen Peristrophe japonica. [DOI] 10.1016/j.antiviral.2022.105482 PMC 바로가기
Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2Article Published on 2022-12-152023-07-10 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), [키워드] autophagy COVID-19 Innate immunity Lysosomes. [DOI] 10.1172/JCI160766 PMC 바로가기
Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic controlResearch article Published on 2022-12-012022-10-05 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication [DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article
Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cellsArticle Published on 2022-11-022022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 진단, [키워드] Affect analyses autophagy Better boost cancer cell cancer cell lines Cell cell type ciliated conducted COVID-19 pathology COVID19 Critical eight endocytosed enterocytes experiment expressed Factor Genetic genetic screen Gut help Host host cell human cell human lung identify impair Infection Interaction lentiviruses loss-of-function lysosomal lysosomal membrane overexpression plac8 plasma Protein regulate respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 viruses secretory cell single-cell SPNS1 spns1. susceptible viral entry viral infection virions [DOI] 10.15252/embj.2022110727 PMC 바로가기
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression TMPRSS2. uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기